| Pre-Approval | Contact VRDL.Submittal@cdph.ca.gov for pre-approval. Please provide all of the supplemental information requested for a complete and accurate assessment.
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Supplemental Information Requested
| - Travel location(s)
- Please note any travel to an area with documented or suspected Oropouche virus circulation within two weeks of initial symptom onset (as patients may experience recurrent symptoms).
- Use CDC Oropouche in the Americas webpage to review areas with reported cases of Oropouche.
- Travel dates
- Symptom onset date
- Symptoms
- fever
- headache
- myalgia
- arthralgia
- photophobia
- retroorbital/eye pain
- signs and symptoms of neuroinvasive disease (e.g., stiff neck, altered mental status, seizures, limb weakness, or cerebrospinal fluid pleocytosis)
- Co-morbidities
- Immunocompromising medications
- Pregnancy status
- Please include gestational age or estimated date of delivery.
- Dates and results of previous testing for other arboviruses, in particular dengue virus.
- All specimen type(s) available
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| Submittal Form | Specimens must be accompanied with a hard copy of the completed VRDL General Purpose Specimen Submittal Form (PDF) or a form generated in the VRDL Lab Web Portal. |
| Methodology (Commercial Test Name or Laboratory Developed Test (LDT)) | Reverse transcription real time PCR (Surveillance use only)
Please note that specimens received at VRDL will be split: 0.5 mL will be sent to CDC for molecular testing.
If specimen is collected 6–7 days post onset and tests RT-PCR negative, an aliquot will be sent to CDC for serological testing.
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| Reflex Testing | None |
| Acceptable Specimen Type(s) and Collection Method | Human specimens: - Serum:
- Plain Red-Top Tubes: Serum collected in plain, red-top tubes must be separated and transferred to sterile, screw-cap tubes for storage and transport.
- Serum Separator Tubes (SST): SST may be transported after centrifugation.
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| Minimum Volume Requested | |
| Transport Medium (if applicable) | Not Applicable |
| Specimen Labeling | Each specimen tube must be labeled with at least two unique patient identifiers, e.g., patient full name and date of birth. |
| Storage & Preservation of Specimen / Shipping Conditions | - Separated Serum: Refrigerate or freeze separated serum promptly after collection.
- Serum Separator Tubes: Refrigerate, do not freeze.
Ship refrigerated specimens to VRDL on cold packs. Ship frozen specimens to VRDL on dry ice. |
Shipping Instructions | Work with your local public health department to ensure samples are packaged according to instructions for Biological Substance – Category B (UN 3373) shipment. Ship specimens and a hard copy of the completed submittal forms to: CDPH VRDL ATTN: Specimen Receiving 850 Marina Bay Parkway Richmond, CA 94804 Phone: 510-307-8585 |
| Turnaround Time | 10 Business Days |
| Limitations | Negative result does not preclude the possibility of infection. |
| Additional Information |
Specimens should be collected as close to illness onset as possible and no longer than 7 days after onset unless timing of onset is unclear.
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| VRDL Points of Contact | Medical and Epidemiology Liaisons: (510) 307-8585 or VRDL.submittal@cdph.ca.gov
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