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prenatal screening program

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Information for Individuals and Families

Pregnancy can cause feelings of joy, as well as fear, stress, and uncertainty about the future. Some expecting parents want to know as much as they can about their fetus (developing baby) during pregnancy.

Positive pregnancy test  

Prenatal screening offered through the California Prenatal Screening Program is a way to check on your fetus during pregnancy for genetic conditions and birth defects. You decide if you want prenatal screening. Your prenatal care provider should discuss this information and your choice with you early in your pregnancy.

The California Prenatal Screening Program screens for the following genetic conditions and birth defects:

  • Down syndrome (trisomy 21); 
  • Trisomy 18; 
  • Trisomy 13; and
  • Neural tube defects, like spina bifida.
Starting in spring or summer 2024, sex chromosome differences will join the list of what is screened for by the California Prenatal Screening Program​.

Find out more about prenatal screening from our new videos in English, Spanish, and Chinese below!

​English Video
​Spanish Video
​Chinese Video

Title: California Prenatal Screening Program and Luisa’s Decision

Language: English

Published: 8/11/2022

Duration: 3:29

Title: Programa de Detección Prenatal de California: La decisión de Luisa

Language: Spanish

Published: 8/29/2022

Duration: 4:14

Title: 加州产前筛查计划及路易莎的决定

Language: Simplified Chinese

Published: 9/20/2022

Duration: 3:59


Educational Materials

Prenatal Screening Patient Booklet (12​ Pages)

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​Prenatal Screening Patient Booklet Glossary​ (2 Pages)

Skip to main content​​​English​​ (PDF)​​​​​ 

Prenatal Screening Patient Booklet Summary (2 Pages)

​The summary serves as an additional resource and should not be used as a replacement for the                        comprehensive PNS Program patient booklet. The patient booklet provides detailed information about the PNS Program, including consent and legal notices.​​



Prenatal Screening Patient Booklet (use “select language” button in top right of web page to view in additional languages)

Prenatal Screening Program Co​mmunity Flyer

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Prenatal Screening Social M​edia Toolkit

Prenatal screening is your choice


Please post and share widely with people in California who are or may become pregnant and the groups that serve them!




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