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microbial ​​DISEASES LABORATORY BRANCH

Test Name

​​Carbapenemase-Producing Organism (CPO) Colonization Testing​


Test ​​​​​M​​​e​​th​o​​​​d​​​olog​y​
​​​Carbapenemase genotypic detection: PCR ​​based assay (Xpert Carba-R)

Reflex Te​sting
Criteria

​Not Applicable. ​​

Pre-A​pproval
Required​

​​​Yes, must be approved by CDPH Healthcare Associated Infections (HAI) Program and California Antimicrobial Resistance Laboratory (CARL) Program prior to submission. Please coordinate with HAIProgram@cdph.ca.gov and CARLProgram@cdph.ca.gov ​ to ensure proper submission.

Supp​lemental Information and Requi​​red Form(s)​
​​​Please use MDL AST “Antimicrobial susceptibility testing” form for submission and select “CPO Colonization Screening” on Page 2. Submittal form and instructions for using the MDL Lab Web Portal (LWP can be found are on our website at: Barcode Submission form and submission instructions.
Detailed instructions for filling out and submitting the AST form can be found here: AST instructions​.
For more information on the CPO Swab test, please reference our test announcement ​​Carbapenemase-Producing Organism (CPO) Colonization Testing.​


Required Specimen Type(s)
​​​Rectal swabs collected using Cepheid dual-swab collection device.


Minimum Volume Required

​Not Applicable​

Specimen Stability
​Swabs in the transport tubes can be stored up to 5 days from collection at room temperature (15-28⁰C).​​​

​Rejection Criteria​

  • ​​Samples collected with unacceptable swab collection devices
  • ​​Samples that have not been preapproved for testing 
  • Samples with insufficient or conflicting labelling
  • Leaking samples
  • Specimens shipped or stored at other than room temperature
  • Specimens received past 5 days from collection date
  • ​Specimen/sample types not meeting acceptance criteria (see CPO colonization testing guide)​

Storage/Transport Conditions ​​​

​​Swabs in the transport tubes can be stored up to 5 days from collection at room temperature (15-28⁰C).

Transport Medium,​​
if applicable


​Liquid Stuart transport media included in Cepheid dual swab collection device.​​​

Specimen Labeling

  • ​​Two identifiers, including patient full name, and at least one other identifier (specimen accession number preferred, date of birth, medical record number).
  • Collection date and time 

Shipping Instructions and Specimen Handling Requirements

​​Ship at ambient temperature using appropriate DOT/IATA approved shipping procedures.

Shipping materials may be provided by CDPH’s California Antimicrobial Resistance Laboratory (CARL) Program prior to submission. Please coordinate with CARLProgram@cdph.ca.gov to ensure proper submission.

Ship to:

California Depart​ment of Public Health​
Microbial Diseases Laboratory ​
ATTN:  Bacterial Diseases Section
850 Marina Bay Parkway, Specimen Receiving Room B106
Richmond, CA  94804​​

Specimen Collection Instructions, if applicable

​​Collection instructions available from Cepheid (Rectal/Perirectal Swab PDF​

Turnaround Time

​7 business days
Interferences & Limitations

​​This test is intended for infection control purposes. The PCR assay cannot differentiate between viable and non-viable cells present in the sample.

Reference Range

​Not Applicable
Additional
Information

​None
MDL Point of Contact
​For questions regarding submissions, please email CARLProgram@cdph.ca.gov​ or MDL.Submissions@cdph.ca.gov or call the MDL Bacterial Diseases Section at 510-412-3903 Monday – Friday 8 AM to 5 PM PT​






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