Vaccines

Mpox vaccination helps protect against mpox when given before or shortly after exposure. Two mpox vaccines are currently available in the United States via the Strategic National Stockpile. 

The federal government has allocated JYNNEOS vaccine to Californians. The California Department of Public Health (CDPH) is working with the Centers for Disease Control and Prevention (CDC) and California Local Health Departments to make this vaccine available to communities to provide protection against mpox.  

Although there are no longer any specific “eligibility” criteria for JYNNEOS vaccine, CDC​ and CDP​H continue to update recommendations for the prioritization of JYNNEOS vaccine among high-risk​ communities. Stay up to date on the latest information regarding vaccine strategies for mpox. 

Resources

Vaccine Resources for the General Public:

• Vaccine Q&As - CDPH resource with common questions around mpox vaccination.
• Vaccine Information Statement: Smallpox/Mpox Vaccine (JYNNEOS™) (PDF) - CDC vaccination statement, including administration, adverse reactions, and risks (PDF).  

Vaccine Resources for Healthcare Providers:

• Interim guidance: Intradermal administration of JYNNEOS smallpox and mpox vaccine recommended to extend scarce supplies – CDPH guidance on vaccine administration
• Consideration for Mpox Vaccination – CDC strategies, vaccine information, planning considerations, and vaccine resources.
• EZIZ Vaccine Resources – Mpox vaccination resources on JYNNEOS including vaccine administration and adverse reactions.
• Mpox and Smallpox Vaccine Guidance – CDC guidance on vaccine effectiveness, including vaccine administration and adverse reactions.

• Mpox Vaccine Q&A for Providers and LHD - CDPH guidance regarding vaccine considerations and administrations for health care providers and local health departments. 
  

Vaccine Resources for Local Health Departments:

• Considerations for Mpox Vaccination in California - CDPH guidance for mpox vaccine considerations
  
• Mpox Vaccine Distribution – HHS data on vaccine distribution within the U.S.
• Vaccine Adverse Event Reporting – HHS adverse event reporting tool. 

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