Vaccines

Vaccination helps to protect against mpox when given before or shortly after an exposure. There are two mpox vaccines currently available in the United States via the Strategic National Stockpile. 

At this time, the federal government has allocated a limited number of JYNNEOS vaccine vials to Californians. The California Department of Public Health is working with the Centers for Disease Control and Local Health Departments to make these vials available to protect against mpox.  

CDC and CDPH are continuing to update their recommendations for which communities are being prioritized for JYNNEOS vaccination.  

Stay up to date on the latest information regarding vaccine strategies for mpox.  

Resources

Vaccine Resources for the General Public:

• Vaccine Q&As - CDPH resource with common questions around mpox vaccination.
• Vaccine Information Statement: Smallpox/Mpox Vaccine (JYNNEOS™) (PDF) - CDC vaccination statement, including administration, adverse reactions, and risks (PDF).  

Vaccine Resources for Healthcare Providers:

• Interim guidance: Intradermal administration of JYNNEOS smallpox and mpox vaccine recommended to extend scarce supplies – CDPH guidance on vaccine administration
• Consideration for Mpox Vaccination – CDC strategies, vaccine information, planning considerations, and vaccine resources.
• EZIZ Vaccine Resources – Mpox vaccination resources on JYNNEOS including vaccine administration and adverse reactions.
• Mpox and Smallpox Vaccine Guidance – CDC guidance on vaccine effectiveness, including vaccine administration and adverse reactions.

• Mpox Vaccine Q&A for Providers and LHD - CDPH guidance regarding vaccine considerations and administrations for health care providers and local health departments. 
  

Vaccine Resources for Local Health Departments:

• Vaccine Allocation Calculation Process –CDPH document with details on vaccine allocation to Local Health Jurisdictions.
  
• Considerations for Mpox Vaccination in California - CDPH guidance for mpox vaccine considerations
  
• Mpox Vaccine Distribution – HHS data on vaccine distribution within the U.S.
• Vaccine Adverse Event Reporting – HHS adverse event reporting tool. 

Table 1. Vials Allocated by CDPH and Los Angeles County (LAC) ^1, 2 

Note:  Doses for Los Angeles County are allocated separately by CDC