What is doxy PEP?

In a nutshell, doxycycline post-exposure prophylaxis (doxy PEP) is taking an antibiotic called doxycycline to help prevent the bacterial STIs chlamydia, gonorrhea, and syphilis. It involves taking one 200mg dose of doxycycline orally as soon as possible but no later than three days after having sex without a condom to help prevent bacterial STIs.​

Who can use doxy PEP? ​

Doxy PEP is recommended for certain individuals, including cisgender men and transgender women with a history of bacterial STIs or condomless sex in the past year, to help prevent chlamydia, gonorrhea, and syphilis. Doxy PEP may also be offered to other sexually active individuals who are interested in taking it, after having a conversation discussing the benefits and risks with their health care provider.

Doxy PEP lowers the chance of getting chlamydia, gonorrhea, and syphilis

Recent research shows that doxy PEP reduces the chance of getting a bacterial STI. In one study, it reduced the chance of getting chlamydia or syphilis by over 70%, and the chance of getting gonorrhea by about 50%. That means it prevented more than two out of three chlamydia and syphilis infections and half of gonorrhea infections when taken within 72 hours of condomless sex. It is also safe and effective in people with HIV.​

How do I use doxy PEP to prevent STIs?

It is recommended to take 200mg of doxycycline by mouth within 24 hours (no later than 72 hours) after condomless oral, anal, vaginal and/or front hole sex. You can take doxy PEP as often as every day, but don't take more than 200mg every 24 hours. If you have multiple encounters over a period of time, make sure to take the final dose within 72 hours of your last encounter. Take doxycycline with plenty of water, and if you get an upset stomach, try taking it with food. Avoid high levels of sunlight exposure or wear sun protection for 24 hours after taking doxycycline.​

How can I get doxy PEP? And is it expensive?

Doxy PEP is not expensive but you will need to ask a health care provider for a prescription. If they don't know about it, ask them to visit CDPH and CDC guidelines for more information.

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