Mpox Guidance​

Topics: Health Advisories and Updates |​ For Health Care Providers | For Laboratories | For Local Health Departments | Community Guidance​ | Archived Guidance​​​​​

Health Care Providers

Topics: Clinical Recognition and Considerations | Provider Vaccine Information | ​ Mpox Treatment​ |​ Provider Reporting | Infection Prevention and Waste Management in Healthcare Settings

Clinical Recognition and Considerations

Mpox Treatment

Local Health Departments​

Topics: Case Reporting | Case Investigation and Other Setting-Specific Guidance​ |​ LHJ Vaccine Information | Messaging and Communications Toolkit​

Case Reporting

• Suspected Clade I Mpox Case: Notify CDPH STDCB and CDPH VRDL immediately of any cases with suspected clade I mpox. At this time, all specimens collected from a case with suspected clade I mpox should be sent to your local public health lab and forwarded to CDPH VRDL if the local public health lab does not have clade I testing capabilities.
• CDPH VRDL: (510) 307-8585 or VRDL.submittal@cdph.ca.gov 
• ​CDPH STDCB: (510) 620-3400 or STDCB@cdph.ca.gov | After-hours duty officer: (916) 328-3605
• ​Mpox Case Definition – CDC guidance for surveillance case definitions and criteria, including for reinfections.
• Interim reinfection reporting to CDPH:
• Create new incident ID for suspected reinfection cases and attach ELR.
• ​Assess for case criteria per CDC definition (i.e., symptom resolution between episodes) and note “reinfection” within notes tab along with primary infection incident ID.
• ​If possible, forward any specimens that may meet reinfection criteria to VRDL for WGS.
• Send secure email to stdcb@cdph.ca.gov
• Death reporting – See CDC MMWR on mpox-associated deaths. For public health surveillance in CalREDIE, use the death certificate (i.e., if mpox is listed on the death certificate as a primary or significant contributing factor) for determining mpox associated death.
• ​​​See CalREDIE document repository or LHJ SharePoint for further reporting information—email mpoxadmin@cdph.ca.gov​ to request SharePoint access.
  

Case Investigation and Other Setting-Specific Guidance

• Mpox Quicksheet​ (PDF)—CDPH general guidance quicksheet for local health departments including an overview of mpox clinical characteristics, epidemiology, testing, isolation, and infection prevention guidance for different settings.
  
• ​Isolation and Infection Control at Home​ – CDC isolation guidance for persons with suspected or confirmed mpox infection.
  
• Monitoring and Risk Assessment for Persons Exposed in the Community – CDC guidance for post-exposure risk assessment and monitoring.
  
• Setting-specific guidance:
  
• ​Mpox Guidance for Congregate Settings - CDPH guidance for congregate settings, including homeless shelters and correctional facilities.
• ​Considerations for Reducing Mpox Transmission in Congregate Living Settings ​– CDC guidance for prevention of mpox in congregate settings.
• ​Mpox Considerations for Childcare and School Settings​ – CDPH guidance for administrators and staff of schools and childcare settings. 
  
• Infection Prevention and Control of Mpox in Healthcare Settings – CDC guidance that includes transmission prevention, patient placement and PPE. 
• Workplaces covered by the Cal/OSHA Aerosol Transmissible Diseases (ATD) standard (PDF) should consult those regulations for additional applicable requirements. See  Cal/OSHA: Protecting Workers from Mpox for Employers and Workers Covered by the Aerosol Transmissible Disease Standard (Title 8 Section 5199) (PDF).​
• LHJ staff training:
  
• ​​Mpox Case and Cluster Investigation Protocol for LHDs – requires local health department SharePoint access, email mpoxadmin@cdph.ca.gov​ if you work for an local health department to request access.
  
• Mpox Training for Disease Investigators​ – CAPTC educational video series for DIS with updated content.
  
• Consent to Medical Services for the Treatment of Mpox in Minors – CDPH guidance on obtaining minor consent for health care providers and local health departments.
  

LHJ Vaccine Information​

• CDPH Mpox Vaccination – CDPH information about mpox vaccine and how to find a vaccinating provider.
  
• EZIZ: Mpox Vaccination Resources – CDPH Immunization Branch website with up-to-date information for clinics and local health departments regarding JYNNEOS administration, vaccine ordering, and other resources.
  
• Mpox Vaccination – CDC JYNNEOS vaccine recommendations.
• Note: A limited supply of CDPH-purchased JYNNEOS may be available for LHJ use in outbreaks and/or for certain priority populations (e.g., uninsured, underinsured or with other barriers to care). Email STDCB@cdph.ca.gov​  to request and check availability.
  

Messaging and Communications Toolkits

• CDPH LGBTQ+ Health: Pride Toolkit – CDPH webpage with educational materials (posters, flyers, and sticker files) about mpox and sexual health available in English and Spanish.
  
• Sexual Health​ Campaigns Toolkit – CDPH STD Control Branch webpage with mpox fact sheets, videos, and graphics for community-based organizations and local health departments.
  
• Resources for Event Organizers and Venues:
• ​Pre-event mpox recommendation template (PDF): Template with up-to-date information that venues or event organizers can use to inform attendees of mpox risk and preventative steps.