Skip Navigation LinksIN-Y-90-Microspheres Information Notice 25-01 - Y-90

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EDMUND G. BROWN JR.
Governor

State of California—Health and Human Services Agency
California Department of Public Health


Information Notice 25-01
October 10, 2025


TO:
Medical Use Licensees Authorized to Use Y-90 Microspheres (10 CFR 35.1000)

SUBJECT:
Nuclear Regulatory Commission Information Notice 2025-05

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The U.S. Nuclear Regulatory Commission (NRC) recently issued Information Notice (IN) 2025-05 to inform licensees of recent medical events involving the unintended gastrointestinal disposition of Y-90 microspheres. The Radiologic Health Branch (RHB) is providing this IN to California medical-use licensees with authorization for Y-90 microspheres, as permitted by 10 CFR 35.1000.

​The IN can be found here: https://www.nrc.gov/docs/ML2517/ML25178A313.pdf

Licensees are advised to review this information to be better equipped to prevent similar events at their own facilities.

​Should you have any questions, please contact Robert Custodio by telephone at (916) 650-0561, by email at Robert.Custodio@cdph.ca.gov; or Ira Schneider by telephone at (916) 440-7976 or by email at Ira.Schneider@cdph.ca.gov




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