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Division of Communicable Disease Control

Monkeypox (MPX)

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Find support for your community with the latest Monkeypox mitigation tools. Please connect with your Medical and Health Operational Area Coordinator (MHOAC) (PDF) for contract tracing resources and assistance.

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Check with your local health department (LHD) for more information on case reporting and treatment options available.

 

 

General251General<ul><li><p><a href="/Programs/CID/DCDC/Pages/MPX/MPX-Home-Isolation-Guidance-for-the-General-Public.aspx">MPX Home Isolation Guidance for the General Public</a> | <a href="/Programs/CID/DCDC/CDPH%20Document%20Library/Monkeypox/Monkeypox-Home-Isolation-Guidance--es.pdf">Spanish</a> (PDF)<br></p></li><li><p><a href="/Programs/CID/DCDC/Pages/Intradermal-administration-of-JYNNEOS-smallpox-and-monkeypox-vaccine-recommended-to-extend-scarce-supplies.aspx">Intradermal Administration of JYNNEOS Smallpox and MPX Vaccine Recommended to Extend Scarce Supplies</a> | <a href="/Programs/CID/DCDC/CDPH%20Document%20Library/Monkeypox/Interim-guidance-Intradermal-administration-of-JYNNEOS-smallpox-and-MPX--es.pdf">Spanish</a> (PDF) <br></p></li><li><p><a href="/Programs/CID/DCDC/Pages/MPX/Monkeypox-Guidance-for-Congregate-Living-Settings.aspx">MPX Guidance for Congregate Living Settings</a><br></p></li><li><p><a href="/Programs/CID/DCDC/Pages/MPX/MPX-Consideration-for-Childcare-and-School-Settings.aspx">MPX Consideration for Childcare and School Settings</a> | <a href="/Programs/CID/DCDC/CDPH%20Document%20Library/Monkeypox/Monkeypox-Considerations-for-Childcare-and-School-Settings--es.pdf">Spanish</a> (PDF)<br></p></li></ul>

 

 

Case Definition, Diagnosis and Reporting255Case Definition, Diagnosis and Reporting<div><ul style="box-sizing:border-box;margin-top:0px;margin-bottom:10px;"><li><p>​<a href="/Programs/CID/DCDC/Pages/Clinical-Assist-Tool-for-Monkeypox-Evaluation.aspx" target="_blank" rel="noreferrer noopener">Clinical Assist Tool for MPX Evaluation</a><span data-contrast="auto" lang="EN-US"> – CDPH guidance tool to aid clinicians in determining MPX diagnosis.</span><span data-ccp-props="{"134233117":true,"134233118":true}"> </span></p></li><li><p><a href="/Programs/CID/DCDC/Pages/MPX/MPX-Home-Isolation-Guidance-for-the-General-Public.aspx" target="_blank" rel="noreferrer noopener">CDPH Guidance on the Isolation of MPX Patients at Home</a><span data-contrast="none" lang="EN-US"> </span><span data-contrast="auto" lang="EN-US">-</span><span data-contrast="none" lang="EN-US"> </span><span data-contrast="auto" lang="EN-US">CDPH</span><span data-contrast="auto" lang="EN-US"> </span><span data-contrast="auto" lang="EN-US">guidance on the isolation of MPX patients at home.</span><span data-ccp-props="{"134233117":true,"134233118":true}"> </span></p></li><li><p><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/clinical-recognition.html" target="_blank" rel="noreferrer noopener">Clinical Recognition</a><span data-contrast="auto" lang="EN-US"> – CDC guidance on key MPX characteristics, clinical prodrome, and rash development.</span><span data-ccp-props="{"134233117":true,"134233118":true}"> </span></p></li><li><p><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/clinical-guidance.html" target="_blank" rel="noreferrer noopener">CDC Clinical Guidance </a><span data-contrast="auto" lang="EN-US"> – CDC guidance for healthcare providers for managing patients with MPX.</span><span data-ccp-props="{"134233117":true,"134233118":true}"> </span></p></li></ul></div>
Information for Laboratories Performing MPX Testing256Information for Laboratories Performing MPX Testing<ul style="box-sizing:border-box;margin-top:0px;margin-bottom:10px;color:#202020;font-family:"source sans pro", sans-serif;font-size:18px;background-color:#ffffff;"><li><p>​<a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/prep-collection-specimens.html" target="_blank">Preparation and Collection of Specimens</a> – CDC best practices for specimen collection, storage, and shipment of specimens for MPX diagnosis. <span class="NormalTextRun SCXW74294045 BCX8" style="margin:0px;padding:0px;color:#000000;font-family:"source sans pro", "source sans pro_embeddedfont", sans-serif;font-size:18px;white-space:pre-wrap;background-color:#ffffff;">Please note,</span><span class="NormalTextRun SCXW74294045 BCX8" style="margin:0px;padding:0px;color:#000000;font-family:"source sans pro", "source sans pro_embeddedfont", sans-serif;font-size:18px;white-space:pre-wrap;background-color:#ffffff;"> specimens do not need to be unroofed; vigorous swabbing of the lesion is sufficient.</span><br></p></li><li><p>Commercial laboratories providing MPX testing:<br></p></li><ul style="box-sizing:border-box;margin-top:0px;margin-bottom:0px;"><li><p><a href="https://www.labcorp.com/infectious-disease/monkeypox" target="_blank">LabCorp MPX (Orthopoxvirus), DNA, PCR Test</a> – Labcorp resource on MPX tests.<br></p></li><li><p><a href="https://testdirectory.questdiagnostics.com/test/test-detail/12084/monkeypox-virus-dna-qualitative-real-time-pcr?q=monkeypox&cc=MASTER" target="_blank">Quest Diagnostics MPX Virus DNA, Qualitative Real-Time PCR </a>- Quest Diagnostics resource on test details and FAQs.</p></li><li><p><a href="https://www.mayocliniclabs.com/order-tests">MPX Mayo Clinic Lab Ordering</a> – main page for ordering tests from Mayo Clinic.</p></li><li><p><a href="https://www.aegislabs.com/our-services/monkeypox/" target="_blank">MPX Aegis Sciences Corporation PCR Testing</a>- main page for ordering tests from Aegis Sciences.</p></li><li><p><a href="https://www.sonichealthcareusa.com/about-us/news/2022/07/sonic-healthcare-usa-announces-testing-availability-for-monkeypox/" target="_blank">MPX Testing Sonic Healthcare USA</a> -main page for ordering tests from Sonic Healthcare.</p></li></ul><li style="box-sizing:border-box;"><p><a href="https://www.cdc.gov/poxvirus/monkeypox/lab-personnel/index.html" target="_blank">Information for Laboratory Personnel</a> – CDC information on laboratory procedures and testing, including RT-PCR assays and PPE.<br></p></li></ul>
Prevention and Management in Healthcare Settings257Prevention and Management in Healthcare Settings<ul style="box-sizing:border-box;margin-top:0px;margin-bottom:10px;color:#202020;font-family:"source sans pro", sans-serif;font-size:18px;background-color:#ffffff;"><li><p><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/infection-control.html" target="_blank">Infection Control </a> - CDC guidance that includes transmission prevention, patient placement and PPE.<br></p></li><li><p><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/infection-control-healthcare.html?CDC_AA_refVal=https://www.cdc.gov/poxvirus/monkeypox/clinicians/infection-control-hospital.html" target="_blank" rel="noreferrer noopener">Infection Prevention and Control of MPX in Healthcare Settings</a><span data-contrast="auto" lang="EN-US"> – CDC guidance that includes transmission prevention, patient placement and PPE.</span><span data-ccp-props="{"134233117":true,"134233118":true}"> </span></p></li><li><p><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/monitoring.html" target="_blank">Monitoring People Who Have Been Exposed</a> - CDC guidelines for monitoring people who were exposed to confirmed infected animals or people. <br></p></li></ul>
Clinical Considerations in Special Populations258Clinical Considerations in Special Populations<ul style="box-sizing:border-box;margin-top:0px;margin-bottom:10px;color:#202020;font-family:"source sans pro", sans-serif;font-size:18px;background-color:#ffffff;"><li><p>​<a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/pregnancy.html#:~:text=Monkeypox%20and%20Pregnancy%2c-Data%20regarding%20monkeypox&text=Monkeypox%20virus%20can%20be%20transmitted%2cconfirmed%20monkeypox%20infection%20during%20pregnancy." target="_blank">Clinical Consideration for MPX in People Who are Pregnant or Breastfeeding</a> - CDC guidance for MPX infection in people who are pregnant and/or breastfeeding.</p></li><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/people-with-HIV.html" target="_blank" style="box-sizing:border-box;color:#0071bc;background-color:transparent;outline:none;">Clinical Consideration for Treatment and Prophylaxis of MPX Virus Infection in People with HIV</a> -   CDC guidance for patients with HIV who might or have been exposed to MPX.</p></li><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"> <a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/pediatric.html" style="box-sizing:border-box;color:#0071bc;background-color:transparent;outline:none;">Clinical Consideration for MPX in Children and Adolescents</a> – CDC guidance for healthcare providers assisting those under the age of 18. <br></p></li></ul>
Management259Management<ul style="box-sizing:border-box;margin-top:0px;margin-bottom:10px;color:#202020;font-family:"source sans pro", sans-serif;font-size:18px;background-color:#ffffff;"><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"><a href="/Programs/CID/DCDC/Pages/MPX/Supportive-Care-Suggestions.aspx" style="box-sizing:border-box;color:#0071bc;background-color:transparent;outline:none;">Supportive Care Guidance</a> - CDPH guidance on supportive care measures for patients. <br style="box-sizing:border-box;"></p></li><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"><a href="/Programs/CID/DCDC/Pages/MPX/MPX-Tecovirimat-Treatment-Information-for-Providers.aspx" style="box-sizing:border-box;color:#0071bc;background-color:transparent;outline:none;">MPX Tecovirimat Treatment Information for Providers</a> - CDPH clinical guidance on treatment of MPX with Tecovirimat.<br style="box-sizing:border-box;"></p></li><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"><a href="/Programs/CID/DCDC/Pages/MPX/Consent-to-Medical-Services-for-the-Treatment-of-MPX-in-Minors.aspx" style="box-sizing:border-box;color:#0071bc;background-color:transparent;outline:none;">Consent to Medical Services for the Treatment of Monkeypox (MPX) in Minors</a> - CDPH guidance on obtaning minor consent for health care providers and local health departments.<br style="box-sizing:border-box;"></p></li><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/treatment.html" target="_blank" style="box-sizing:border-box;color:#0071bc;background-color:transparent;outline:none;">Treatment Information for Healthcare Professionals</a> - CDC interim clinical guidance and medical counter measures (including TPOXX) available for treatment of MPX.<br></p></li><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/pain-management.html">Clinical Considerations for Pain Management of Monkeypox | Monkeypox | Poxvirus | CDC</a> - CDC <span data-contrast="auto" lang="EN-US" class="TextRun SCXW240742710 BCX8" style="alignment-baseline:auto;backface-visibility:visible;baseline-shift:0px;border-color:#000000;border-collapse:separate;border-width:0px;border-style:none;border-spacing:0px;border-radius:0px;box-shadow:none;box-sizing:content-box;caption-side:top;clear:none;clip:auto;clip-path:none;clip-rule:nonzero;color:#000000;color-interpolation:srgb;color-interpolation-filters:linearrgb;color-rendering:auto;columns:auto auto;column-fill:balance;column-rule:0px none #000000;column-span:none;counter-increment:none;counter-reset:none;cursor:text;direction:ltr;display:inline;dominant-baseline:auto;empty-cells:show;fill:#000000;fill-opacity:1;fill-rule:nonzero;flex:0 1 auto;flex-flow:row nowrap;float:none;flood-color:#000000;flood-opacity:1;font-family:wordvisi_msfontservice, "source sans pro", "source sans pro_embeddedfont", sans-serif;font-feature-settings:normal;font-size:18px;height:auto;image-rendering:auto;lighting-color:#ffffff;line-break:auto;line-height:21px;list-style:outside none disc;margin:0px;mask:none;max-height:none;max-width:none;min-height:0px;min-width:0px;opacity:1;order:0;outline:#000000 none 0px;overflow:visible;padding:0px;perspective:none;perspective-origin:0px 0px;pointer-events:auto;ruby-position:over;shape-rendering:auto;speak:normal;stop-color:#000000;stop-opacity:1;stroke:none;stroke-dasharray:none;stroke-dashoffset:0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:4;stroke-opacity:1;stroke-width:1px;table-layout:auto;text-align-last:auto;text-anchor:start;text-decoration-style:solid;text-decoration-color:#000000;text-emphasis-position:over;text-overflow:clip;text-rendering:auto;text-shadow:none;text-underline-position:auto;transform-origin:0px 0px;transform-style:flat;transition:all 0s ease 0s;unicode-bidi:normal;vertical-align:baseline;visibility:visible;white-space:pre-wrap;width:auto;word-break:normal;writing-mode:horizontal-tb;z-index:auto;zoom:1;"><span class="NormalTextRun SCXW240742710 BCX8">guidance on pain management</span></span>.</p></li><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/obtaining-tecovirimat.html" target="_blank" style="box-sizing:border-box;color:#0071bc;background-color:transparent;outline:none;">Obtaining and Using TPOXX (Tecovirimat)</a> - CDC guidance how to request TPOXX through the Strategic National Stockpile.</p></li><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"><a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/Tecovirimat.html#anchor_1654624274659" target="_blank" style="box-sizing:border-box;color:#0071bc;background-color:transparent;outline:none;">Guidance for Tecovirimat Use Under Expanded Access Investigational New Drug Protocol during 2022 U.S. MPX Cases</a> – CDC guidance regarding Tecovirimat use.<br></p></li></ul>

 

 

Infection Control253Infection Control<ul><li><p><a href="/Programs/CID/DCDC/Pages/MPX/MPX-Guidance-for-Homeless-Service-Providers.aspx">MPX Guidance for Homeless Service Providers</a> - CDPH guidance for homeless shelter operators and providers <br></p></li><li><p><a href="/Programs/CID/DCDC/Pages/MPX/MPX-Guidance-for-Correctional-Facilities.aspx">MPX Guidance for Correctional Facilities</a> | <a href="/Programs/CID/DCDC/CDPH%20Document%20Library/Monkeypox/Monkeypox-MPX-Infection-Control-Guidance--es.pdf">Spanish (PDF) </a>- CDPH guidance for state and local correctional facilities<br></p></li><li><p><a href="/Programs/CID/DCDC/CDPH%20Document%20Library/Monkeypox/MPX-outbreak-quicksheet.pdf">MPX Investigation Quicksheet</a> - CDPH quicksheet for local health departments <br></p></li></ul>
Case Reporting260Case Reporting<ul style="box-sizing:border-box;margin-top:0px;margin-bottom:10px;color:#202020;font-family:"source sans pro", sans-serif;font-size:18px;background-color:#ffffff;"><li><p><a href="/Programs/CID/DCDC/Pages/MPX/MPX-Exposure-Management.aspx">MPX Exposure Management</a> – CDPH guidance regarding recommendations for management of persons with possible exposure to someone with monkeypox (MPX) in community settings. <br></p></li><li style="box-sizing:border-box;"><p><a href="https://www.cdc.gov/poxvirus/monkeypox/healthdepts/case-reporting.html">Case Reporting Recommendations for Health Departments</a> – CDC guidance for health department reporting. <br></p></li></ul>
Vaccine Distribution and Administration261Vaccine Distribution and Administration<ul style="box-sizing:border-box;margin-top:0px;margin-bottom:10px;color:#202020;font-family:"source sans pro", sans-serif;font-size:18px;background-color:#ffffff;"><li><p><a aria-label="Link Prioritizing inventory of JYNNEOS smallpox and monkeypox vaccine (ca.gov)" href="/Programs/CID/DCDC/Pages/Monkeypox-vaccine-doses.aspx" rel="noopener noreferrer" target="_blank" tabindex="-1">Prioritizing inventory of JYNNEOS smallpox and monkeypox vaccine</a> – Updated guidance on administering 2nd doses at recommended 28 day interval<br></p></li><li style="box-sizing:border-box;"><p style="box-sizing:border-box;"><a href="/Programs/CID/DCDC/Pages/MPX/Consent-to-Medical-Services-for-the-Treatment-of-MPX-in-Minors.aspx" style="box-sizing:border-box;color:#205493;outline:none;font-size:1em;">Consent to Medical Services for the Treatment of Monkeypox (MPX) in Minors</a><span style="box-sizing:border-box;font-size:1em;"> - CDPH guidance on obtaning minor consent for health care providers and local health departments.</span></p></li><li><p><a href="/Programs/CID/DCDC/Pages/Considerations-for-Expanded-Monkeypox-Post-Exposure-Prophylaxis.aspx">Considerations for MPX Vaccination in California</a> - CDPH guidance on priority populations for vaccination, venues to consider vaccine administration and health education considerations<br></p></li><li><p><a href="/Programs/CID/DCDC/Pages/Intradermal-administration-of-JYNNEOS-smallpox-and-monkeypox-vaccine-recommended-to-extend-scarce-supplies.aspx">Interim guidance: Intradermal administration of JYNNEOS smallpox and monkeypox vaccine recommended to extend scarce supplies</a> - CDPH guidance on intradermal administration<br><br></p></li></ul>

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