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California Rabies Compendium - List of Licensed Animal Rabies Vaccines

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Detailed guidance on rabies prevention and control is available in the California Compendium of Rabies Control and Prevention (PDF).

California Rabies Compendium – List of U.S. Licensed Animal Rabies Vaccines

California Health & Safety Code (§121690) requires that all dogs over the age of three months must be vaccinated against rabies with a vaccine approved by the California Department of Public Health and administered according to the vaccine label. California regulations (California Code of Regulations, Title 17, §2651) specify that canine rabies vaccines must meet a minimum potency standard and have a duration of immunity of at least three years to be approved for use in California.

Route of Administration: Approved canine vaccines must be administered to dogs according to the manufacturers' recommendations either intramuscularly (IM) or subcutaneously (SC). Administration via other routes may reduce effectiveness or be unsafe. For species other than dogs, refer to the vaccine label.

A) Monovalent – Inactivated

Product	Licensed and Labeled for Use	Approved by CDPH for Use in Dogs in California?	Dosage	Route of Administration	Minuimum Age at Primary Vaccination	Booster Recommendation
VANGUARD® RABIES 1 YEAR Produced by: Zoetis License No. 190 Marketed by: Zoetis	Dogs Cats Ferrets	No	1 ml	SC	12 weeks	Annually
VANGUARD® RABIES 3 YEAR VANGUARD® RABIES 3 YEAR (CA) Produced by: Zoetis License No. 190 Marketed by: Zoetis	Dogs Cats Ferrets	Yes	1 ml	IM or SC (dogs) SC (cats, ferrets)	3 months (dogs) 12 weeks (cats, ferrets)	1 year later, then triennially (dogs, cats) Annually (ferrets)
VANGUARD® RABIES 3 YEAR Produced by: Zoetis License No. 190 Marketed by: Zoetis	Sheep Cattle	N/A	2 ml	IM	12 weeks	Annually
Nobivac® 1-Rabies Produced by: Merck Animal Health License No. 190 Marketed by: Intervet Inc.	Dogs Cats Ferrets	No	1 ml	SC	12 weeks	Annually
Nobivac® 3-Rabies Produced by: Merck Animal Health License No. 190 Marketed by: Intervet Inc.	Dogs Cats Ferrets	Yes	1 ml	IM or SC (dogs) SC (cats, ferrets)	3 months (dogs) 12 weeks (cats, ferrets)	1 year later, then triennially (dogs, cats) Annually (ferrets)
Nobivac® 3-Rabies CA Produced by: Merck Animal Health License No. 190 Marketed by: Intervet Inc.	Dogs Cats	Yes	1 ml	IM or SC (dogs) SC (cats)	3 months (dogs) 12 weeks (cats)	1 year later, then triennially
Nobivac® 3-Rabies Nobivac® 3-Rabies CA Produced by: Merck Animal Health License No. 190 Marketed by: Intervet Inc.	Sheep Cattle	N/A	2 ml	IM	12 weeks	Annually
Prestige® EquiRab® Produced by: Merck Animal Health License No. 165A Marketed by: Intervet Inc.	Horses	N/A	1 ml	IM	4 months	1 year later, then every 14 months
Rabvac™ 1 Produced by: Elanco License No. 196 Marketed by: Elanco	Dogs Cats	No	1 ml	IM or SC (cats)	3 months	Annually
Rabvac™ 3 Produced by: Elanco License No. 196 Marketed by: Elanco	Dogs Cats	Yes	1 ml	IM or SC	3 months	1 year later, then triennially
Rabvac™ 3 Produced by: Elanco License No. 196 Marketed by: Elanco	Horses	N/A	2 ml	IM	3 months	Annually
IMRAB® 1 IMRAB® 1 TF Produced by: Merial Inc. License No. 298 Marketed by: Merial Inc.	Dogs Cats	No	1 ml	IM or SC (cats)	12 weeks	Annually
IMRAB® 3 IMRAB® 3 TF Produced by: Merial Inc. License No. 298 Marketed by: Merial Inc.	Dogs Cats Ferrets	Yes	1 ml	IM or SC (dogs, cats) SC (ferrets)	3 months (dogs) 12 weeks (cats, ferrets)	1 year later, then triennially (dogs, cats) Annually (ferrets)
IMRAB® 3 Produced by: Merial Inc. License No. 298 Marketed by: Merial Inc.	Sheep Cattle Horses	N/A	2 ml	IM	12 weeks	1 year later, then triennially (sheep) Annually (cattle, horses)
IMRAB® Large Animal Produced by: Merial Inc. License No. 298 Marketed by: Merial Inc.	Sheep Horses Cattle	N/A	2 ml	IM or SC	3 months	Annually (cattle, horses) 1 year later, then triennially (sheep)

B) Monovalent – RNA Particle

Product	Licensed and Labeled for Use	Approved by CDPH for Use in Dogs in California?	Dosage	Route	Minimum Age at Primary Vaccination	Booster Recommendation
Nobivac® NXT Canine-1 Rabies Produced by: Merck Animal Health License No. 165A Marketed by: Intervet Inc.	Dogs	Yes	0.5 ml	SC	3 months	1 year later, then triennially
Nobivac® NXT Feline-3 Rabies Produced by: Merck Animal Health License No. 165A Marketed by: Intervet Inc.	Cats	N/A	0.5 ml	SC	12 weeks	1 year later, then triennially

Product

Licensed and Labeled for Use

Approved by CDPH for Use in Dogs in California?

Dosage

Route

Minimum Age at Primary Vaccination

Booster Recommendation

Nobivac® NXT Canine-1 Rabies

Produced by: Merck Animal Health

License No. 165A

Marketed by: Intervet Inc.

Dogs

Yes

0.5 ml

3 months

1 year later, then triennially

Nobivac® NXT Feline-3 Rabies

Produced by: Merck Animal Health

License No. 165A

Marketed by: Intervet Inc.

Cats

N/A

0.5 ml

12 weeks

1 year later, then triennially

C) Monovalent – Rabies Glycoprtein, Live Canary Pox Vector

Product	Licensed and Labeled for Use	Approved by CDPH for Use in Dogs in California?	Dosage	Route	Minimum Age at Primary Vaccination	Booster Recommendation
PUREVAX® Feline Rabies 1 YR PUREVAX® Feline Rabies 3 YR Produced by: Merial Inc. License No. 298 Marketed by: Merial Inc.	Cats	N/A	1 ml	SC	12 weeks	Annually (1 YR vaccine) 1 year later, then triennially (3 YR vaccine)

Product

Licensed and Labeled for Use

Approved by CDPH for Use in Dogs in California?

Dosage

Route

Minimum Age at Primary Vaccination

Booster Recommendation

PUREVAX® Feline Rabies 1 YR 

PUREVAX® Feline Rabies 3 YR

Produced by: Merial Inc.

License No. 298

Marketed by: Merial Inc.

Cats

N/A

1 ml

12 weeks

Annually (1 YR vaccine)

1 year later, then triennially (3 YR vaccine)

D) Combination – Inactivated Rabies

Product	Licensed and Labeled for Use	Approved by CDPH for Use in Dogs in California?	Dosage	Route	Minimum Age at Primary Vaccination	Booster Recommendation
Equine POTOMAVAC® + IMRAB® Produced by: Merial Inc. License No. 298 Marketed by: Merial Inc.	Horses	N/A	1 ml	IM	3 months	Annually

Product

Licensed and Labeled for Use

Approved by CDPH for Use in Dogs in California?

Dosage

Route

Minimum Age at Primary Vaccination

Booster Recommendation

Equine POTOMAVAC® + IMRAB®

Produced by: Merial Inc.

License No. 298

Marketed by: Merial Inc.

Horses

N/A

1 ml

3 months

Annually

E) Combination - Rabies Glycoprotein, Live Canary Pox Vector

Product	Licensed and Labeled for Use	Approved by CDPH for Use in Dogs in California?	Dosage	Route	Minimum Age at Primary Vaccination	Booster Recommendation
PUREVAX® Feline 3/Rabies 1 Yr PUREVAX® Feline 4/Rabies 1 Yr Produced by: Merial Inc. License No. 298 Marketed by: Merial Inc.	Cats	N/A	1 ml	SC	8 weeks	3-4 weeks later, then annually

Product

Licensed and Labeled for Use

Approved by CDPH for Use in Dogs in California?

Dosage

Route

Minimum Age at Primary Vaccination

Booster Recommendation

PUREVAX® Feline 3/Rabies 1 Yr

PUREVAX® Feline 4/Rabies 1 Yr

Produced by: Merial Inc.

License No. 298

Marketed by: Merial Inc.

Cats

N/A

1 ml

8 weeks

3-4 weeks later, then annually

Revised November 21, 2025

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rabies

California Rabies Compendium – List of U.S. Licensed Animal Rabies Vacci​nes​

​​A) Monovale​​nt – Inactiva​ted​​

​B) Monovalent – RNA Par​ticle​​

C) Monovalent – Rabies Glycoprtein, Live Canary Pox​ Vecto​r ​​

D) Combination – Inactivated Rabies

E) Combination - Rabies Glycoprotein, Live Canary Pox Vector

California Rabies Compendium – List of U.S. Licensed Animal Rabies Vaccines

A) Monovalent – Inactivated

B) Monovalent – RNA Particle

C) Monovalent – Rabies Glycoprtein, Live Canary Pox Vector