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Genetic disease screening program (GDSP)


Nuchal Translucency Practitioners

In March 2009, the California Prenatal Screening (PNS) Program expanded to incorporate first-trimester serum analytes and nuchal translucency (NT) examination data to provide first-trimester combined screening for Down syndrome and Trisomy 18. The PNS Program accepts NT data only from NT practitioners who are actively credentialed by the Nuchal Translucency Quality Review Program (NTQR) or the Fetal Medicine Foundation (FMF) and who are registered with the California PNS Program. A full list of registered practitioners is available on the Prenatal Screening Program website, in the Resources for Patients section.

 Practitioners may submit their NT data online by creating a Screening Information System (SIS) account. In order to create a SIS account, you must:

  1. Be a credentialed NT practitioner or be a genetic counselor, or a licensed medical professional, or a certified medical assistant associated with a credentialed NT practitioner.

  2. Complete the SIS NT Online Training (see links on the left) and let us know, via email, that you have done so.

  3. Sign the SIS Oath of Confidentiality and send it by fax to 510-412-1560 or email to

  4. If you are not an NT practitioner, you will be asked to verify that you are a genetic counselor, other licensed medical professional, or certified medical assistant.  Medical Assistants can be granted SIS access if they are credentialed by any of the four Medical Board of California approved programs.  Or by any program from the Medical Assistant Certification web site that is not an online program (public, private, or campus qualifies), including out of state programs if necessary. 

  5. If you are not an NT practitioner, have a credentialed NT practitioner sign and submit a Letter of Association by fax to 510-412-1560 or by email to

  6. Once the department receives all the required information, a SIS account will be created within 3 to 5 business days.

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