Is fluoride an enzyme poison-does it inhibit the activity of enzymes in humans? No.
No evidence exists that demonstrates that fluoride used in laboratory studies at the optimal level inhibits or impairs human enzyme activity. The fluoride concentrations used in these studies which promoted chemical changes and impaired enzyme metabolism were hundreds of times greater than the concentrations normally found in the body (Simons, 1965). The World Health Organization claims that "No evidence has yet been provided that fluoride ingested at 1 ppm in the drinking water affects intermediary metabolism of food stuffs, vitamin utilization or either hormonal or enzymatic activity." (Jenkins, et al, 1970.)
Simons, J., ed. 1965. Fluorine Chemistry. New York, Academic Press, 176-89.
Jenkins, G., Venkateswarlu, P., and lpkin, I. 1970. Physiological effects of small doses of fluoride. [In Fluorides and Human Health (monograph series #59) World Health Organization, Geneva, Switzerland, p.163-2241.
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