Birth Defect Information - Exposures and Risk Factors
When discussing exposures and risk factors in regards to birth defects, we are talking about anything the fetus is exposed to as well as anything that may alter conditions within the womb. This includes everything the mother may come into contact with during pregnancy. Because most structural development of the fetus occurs during early pregnancy, we focus on what is called the “periconceptional” period – the month before and first 3 months after conception.
Studies cannot always provide a definitive answer about whether a particular exposure, risk factor or both caused a birth defect. Instead, results are reported as changes in birth defects risk for exposed pregnancies compared to unexposed.
Studies that are conducted in order to discover the role of exposures and risk factors on birth defects must validate biologically plausible pathways of exposure – in other words, ways the mother could have been exposed. Proximity is not enough. If a pregnant woman lives near a source of environmental concern, for example, it must also be taken into consideration whether she could have inhaled, ingested or otherwise been exposed to harmful conditions.
The following is a list of exposures and risk factors that may have some impact on a fetus if the mother was exposed during pregnancy:
Please visit the Preconception Health Program website